๐๐ด๐น๐ป๐ฐ:PegUricase.png
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English: A comparison of uricase (pdb:1uox) and PEG-uricase (model). PEG-uricase includes 40 polymers of 10kDa PEG. PEGylation improves its solubility at physiological pH, increases serum half-life and reduces immunogenicity without compromising activity. Upper images show the whole tetramer, lower images show an example of one of the lysines that is PEGylated. (PEG-uricase model from reference[1], only 36 PEG polymers included) |
| Date | |
| ๐ฑ๐๐ฟ๐ฝ๐ฝ๐ฐ | ๐๐ ๐ด๐ ๐ ๐ฐ๐ฟ๐๐๐๐ |
| ๐ฑ๐๐บ๐ฐ๐๐ด๐น๐ | Evolution and evolvability |
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- โ (3 January 2008). "PEG-uricase in the management of treatment-resistant gout and hyperuricemia.". Advanced drug delivery reviews 60 (1): 59-68. PMID 17826865.
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| ๐ผ๐ด๐ป | ๐ป๐ด๐น๐๐น๐ป๐ฐ ๐๐๐น๐๐ฐ๐ท๐๐ | ๐ ๐ฐ๐ท๐๐๐ฟ๐ | ๐ฑ๐๐ฟ๐บ๐พ๐ฐ๐ฝ๐ณ๐/๐ฑ๐๐ฟ๐บ๐พ๐ฐ๐ฝ๐ณ๐น | ๐ ๐ฐ๐ฟ๐๐ณ | |
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| ๐ฝ๐ฟ | 23:50, 21 ๐๐ฐ๐น๐ฑ๐๐ฟ๐ฐ๐๐ด๐น๐ 2015 | | 2,192 ร 2,136 (1.65 MB) | Evolution and evolvability | User created page with UploadWizard |
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