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π†πŒ΄πŒΉπŒ»πŒ°:Serpin mechanism.png

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πŒΌπŒ°πŒΏπ‚πŒ²πŒΏπƒ πƒπŒΊπŒ΄πŒΉπ‚πŒ΄πŒΉπŒ½πƒ

πƒπŒΊπŒ΄πŒΉπ‚πŒ΄πŒΉπŒ½πƒ
English: Serine proteases operate by a two-step catalytic mechanism. First, the substrate (blue) is attacked by the catalytic triad (red) to form an acyl-enzyme intermediate. The intermediate is typically resolved by hydrolysis by water. However, when the reactive centre loop (RCL) of a serpin is attacked, the conformational change (blue arrow) pulls the catalytic triad out of position, preventing it from completing catalysis. (Based on PDB: 1K9O, 1EZX​)
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πŒ±π‚πŒΏπŒ½πŒ½πŒ° πƒπ…πŒ΄πƒ π…πŒ°πŒΏπ‚πƒπ„π…
πŒ±π‰πŒΊπŒ°π‚πŒ΄πŒΉπƒ Thomas Shafee

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